Laboratory of Molecular Genetic Investigation of Internal Diseases

The main directions of scientific research:

  • molecular genetics of cardiovascular diseases (atherosclerosis, myocardial infarction, stroke, hypertension, arrhythmias, sudden cardiac death, etc.).
  • molecular genetics of common therapeutic diseases (type 2 diabetes mellitus, asthma, etc.).
  • molecular genetics of some monogenic diseases (hemochromatosis, ichthyosis vulgaris, MODY-diabetes, familial hypercholesterolemia, etc.).
  • molecular genetics of longevity
  • molecular genetics of non-Hodgkin lymphoma

The laboratory has the equipment and qualified personnel for sequencing and genotyping of DNA samples at any genetic locus.

Laboratory staff regularly participate in Russian and international symposiums, conferences, congresses. The results of the laboratory's research are published in collections of articles, journals (Russian and foreign), in the form of patents.

Head of the laboratory, Higher doctorate of Medical Sciences, Professor

Maksimov Vladimir Nikolaevich

Current work

All conducted research is carried out within the framework of budgetary and extra-budgetary research of the Institute. The last completed budget topic is "Studying the features of the contribution to the predisposition to common cardiovascular diseases of various genome loci in the Russian population”. Within the framework of this topic, the suitability for use in the Russian population as markers of increased risk of myocardial infarction, diabetes mellitus, arterial hypertension of a number of SNPS found in global genome-wide associative studies was tested. The current budget topic is "The study of molecular genetic mechanisms of predisposition to therapeutic diseases in various ethnic groups of Siberia using new generation sequencing technologies to assess the individual genetic risk of their development."

Work is constantly underway to replenish old and form new DNA arrays, for associative research, in the following areas: myocardial infarction, stroke, sudden cardiac death, arrhythmias, arterial hypertension, metabolic syndrome, diabetes mellitus, congenital heart diseases, pneumonia, gallstone disease, longevity.